Because there are many conditions with symptoms that resemble those of PPS, and because no diagnostic test for this disease has yet been identified, the diagnosis is currently one of exclusion. The general criteria for PPS are: new muscle weakness and fatigue in patients with past paralytic polio, with at least 10 years of functional stability, and no other medical or neurologic conditions that can explain the new symptoms. Some studies that can be done to exclude other medical and neurologic conditions include laboratory tests such as blood workups; radiological studies; pulmonary function tests; and electromyographic or EMG studies.

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